Gate 1
Is it real?
Analytical plus biological variation set a noise floor. A delta under the
reference change value is not a finding.
Gate 2
Is it artefact?
Sample handling, biotin, heterophile antibodies, macro-forms, posture, tourniquet.
Free to exclude, and frequently the whole answer.
Gate 3
Is it modifiable?
Drugs, nutrients and behaviour, ranked by prior. Remove the modifier, re-test after
the stated interval, escalate only then.